Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Things like stubbing a toe, burning a finger, putting iodine on a cut, and bumping the “funny bone.” Pain is the most common reason for people to see a doctor. It is also significant in addiction, currently seen in the rampant use and abuse of OxyContin and Vicodin. Darvon, a classic pain drug dating back to the 1950s, was recently removed from the US pharmacopeia by FDA order, citing reproted cardiac arrhythmias, a potentially life-threatening side effect. We discuss the drug, its history and usage or pain drugs, the nociceptor pain receptors, the perception of pain, and its impact on society.